{"id":81761,"date":"2018-06-20T11:59:21","date_gmt":"2018-06-20T11:59:21","guid":{"rendered":"http:\/\/humanitasnet-new.local\/enciclopedia\/acitretin-2\/"},"modified":"2018-06-20T11:59:21","modified_gmt":"2018-06-20T11:59:21","slug":"acitretin-2","status":"publish","type":"enciclopedia","link":"https:\/\/humanitas-net.humweb.webiz.team\/sr\/wiki\/acitretin-2\/","title":{"rendered":"Acitretin"},"content":{"rendered":"<p>Acitretin se u orgnizmu distribuira putem cirkulacije vezan za proteine plazme. Kada dospe u ciljne\u00a0 \u0107elije (epidermalne \u0107elije sa izra\u017eenim stepenom keratinizacije i zapaljenskih elemenata), vezuje se za specifi\u010dne receptore putem reporgramiranja ekspesije gena u samim \u0107elijama).\u00a0 U zavisnosti od tipa \u0107elije, redukuje stepen proliferacije ili modifikuje ekspresiju mediajtora zapaljenske reakcije.<\/p>\n<h2 id=\"sta-je-lek-acitretin\">\u0160ta je lek Acitretin?<\/h2>\n<p>Acitretin je lek koji se koristi u terapiji diskeratoze (abnormalne keratinizacije epidermalnih \u0107elija), te\u0161ke forme psorijaze (uklju\u010duju\u0107i i oblik koji se karaktri\u0161e artropatijom), palmoplantarnom hiperkeratozom i ihtiozom.<\/p>\n<p>&nbsp;<\/p>\n<p>Dovodi do redukcije ko\u017enih promena, crvenila i istanjenja ko\u017ee udru\u017eeih sa primarnim oboljenjem.<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"kako-se-upotrebljava-acitretin\">Kako se upotrebljava Acitretin?<\/h2>\n<p>&nbsp;<\/p>\n<p>Lek se primenjuje peroralno u obliku kapsula, a mogu\u0107a je i primena u vidu injekcija.<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"nezeljeni-efekti-udruzeni-sa-primenom-acitretina\">Ne\u017eeljeni efekti udru\u017eeni sa primenom Acitretina<\/h2>\n<p>Postoji nekoliko ne\u017eeljenih efekata koji mogu nastati tokom upotrebe ovog leka te\u017eina je uslovljena\u00a0 ordiniranom dozom leka kao i trajanjem tretmana.\u00a0 Posebno mo\u017ee usloviti nastanak slede\u0107ih poreme\u0107aja:<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Dermatolo\u0161ki poreme\u0107aji: suve mukozne membrane, zapaljenje o\u010dne i usne duplje, respiratornu zapaljensku reakciju kao i razli\u010dite dermatolo\u0161ke poreme\u0107aje<\/li>\n<li>Mi\u0161i\u0107no-zglobne poreme\u0107aje: artralgija, mijalgija<\/li>\n<li>Neurolo\u0161ke poreme\u0107aje: glavobolja<\/li>\n<li>Hematolo\u0161ke poreme\u0107aje: poreme\u0107aj odre\u0111enih biohemijskih parametara, kao \u0161to su transaminaze<\/li>\n<li>Vaskularne poreme\u0107aje : edem<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2 id=\"kontraiikacije-i-mere-opreza-udruzene-sa-upotrebom-acitretina\">Kontraiikacije i mere opreza udru\u017eene sa upotrebom Acitretina<\/h2>\n<p>Acitretin poseduje izra\u017een teratogeni potencijal (kao \u0161to je na primer\u00a0 utvr\u0111ivanje abnormalnog razvoja fetusa) kao i njegovu mogu\u0107nost\u00a0 deponovanja u odre\u0111enim koli\u010dinima u\u00a0 maj\u010dinom mleku.<\/p>\n<p>Upotreba ovog leka tokom trudno\u0107e i dojenja je kontraindikovana.\u00a0 \u0160tavi\u0161e, tokom trudno\u0107e preporu\u010duje se da se pacijent podvrgnut preventivnom terapeutskom program koji je koristan u redukciji rizika koji su udru\u017eeni sa upotrebom Acitretina.<\/p>\n<p>Upotreba aktivne \u00a0komponente ovog leka tako\u0111e je kontraindikovana\u00a0 kod pacijenata sa o\u0161te\u0107enjem jetre i bubrega kao i kod individua sa poreme\u0107ajima glukoznog i lipidnog metabolizma.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"featured_media":0,"parent":0,"template":"","Example":[1796],"class_list":["post-81761","enciclopedia","type-enciclopedia","status-publish","hentry","enciclopedia_category-aktivni-sastojci"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Acitretin - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"sr_RS\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Acitretin - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Acitretin se u orgnizmu distribuira putem cirkulacije vezan za proteine plazme. Kada dospe u ciljne\u00a0 \u0107elije (epidermalne \u0107elije sa izra\u017eenim stepenom keratinizacije i zapaljenskih elemenata), vezuje se za specifi\u010dne receptore putem reporgramiranja ekspesije gena u samim \u0107elijama).\u00a0 U zavisnosti od tipa \u0107elije, redukuje stepen proliferacije ili modifikuje ekspresiju mediajtora zapaljenske reakcije. \u0160ta je lek Acitretin? 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Kada dospe u ciljne\u00a0 \u0107elije (epidermalne \u0107elije sa izra\u017eenim stepenom keratinizacije i zapaljenskih elemenata), vezuje se za specifi\u010dne receptore putem reporgramiranja ekspesije gena u samim \u0107elijama).\u00a0 U zavisnosti od tipa \u0107elije, redukuje stepen proliferacije ili modifikuje ekspresiju mediajtora zapaljenske reakcije. \u0160ta je lek Acitretin? 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