{"id":81759,"date":"2018-06-20T11:56:25","date_gmt":"2018-06-20T11:56:25","guid":{"rendered":"http:\/\/humanitasnet-new.local\/enciclopedia\/alopurinol\/"},"modified":"2018-06-20T11:56:25","modified_gmt":"2018-06-20T11:56:25","slug":"alopurinol","status":"publish","type":"enciclopedia","link":"https:\/\/humanitas-net.humweb.webiz.team\/sr\/wiki\/alopurinol\/","title":{"rendered":"Alopurinol"},"content":{"rendered":"<p>Hiperurikemija predstavlja klini\u010dko stanje koje se karakteri\u0161e prekomernom koncentracijom mokra\u0107ne kiseline u krvnoj plazmi.<\/p>\n<p>Visoke koncentracije tokom du\u017eeg perioda mogu usloviti nastanak ozbiljnijih poreme\u0107aja kao \u0161to su giht i bubre\u017eni kamenovi.<\/p>\n<p>Pove\u0107ana produkcija mokra\u0107ne kiseline uslovljena je pove\u0107anom aktivno\u0161\u0107u enzima ksantin oksidaze.<\/p>\n<p>Ksantin oksidaza predstavlja enzim sposoban da transformi\u0161e dve supstance \u2013 ksantin i hipoksantin, koji pove\u0107avaju nivo mokra\u0107ne kiseline u organizmu.<\/p>\n<p>&nbsp;<\/p>\n<p>Prema tome, deluje kao inhibitor ksantin oksidaznog sistema.<\/p>\n<p>Alopurinol\u00a0 poseduje sposobnost vezivanja za ksantin oksidazu kao i signifikantnu redukciju<\/p>\n<h2 id=\"sta-predstavlja-alopurinol\">\u0160ta predstavlja alopurinol?<\/h2>\n<p>Alopurinol se primenjuje u le\u010denju hiperurikemije, gihta kao i litijaze nastale usled povi\u0161enih nivoa mokra\u0107ne kiseline.<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"kako-se-primenjuje-lek-alopurinol\">Kako se primenjuje lek Alopurinol?<\/h2>\n<p>&nbsp;<\/p>\n<p>Alopurinol se primenjuje oralno, naj\u010de\u0161\u0107e u formi tableta ili granula u vidu oralnih suspenzija.<\/p>\n<p>&nbsp;<\/p>\n<p>Ne\u017eeljeni efekti udru\u017eeni sa primenom Alopurinolom<\/p>\n<p>&nbsp;<\/p>\n<p>Le\u010denje primenom alopurinola mo\u017ee usloviti nastanak razli\u010ditih ne\u017eeljenih efekata, koji mogu varirati u zavisnosti od individualne osetljivosti, op\u0161teg zdravstvenog stanja, primenjene doze kao i du\u017eine tretmana.<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"u-principu-najcesci-nezeljeni-efekti-alopurinola-podrazumevaju-sledece\">U principu, naj\u010de\u0161\u0107i ne\u017eeljeni efekti Alopurinola podrazumevaju slede\u0107e:<\/h2>\n<p>&nbsp;<\/p>\n<ul>\n<li>Gastrointestinalni poreme\u0107aji : mu\u010dnina, povra\u0107anje, abdominalni bol ;<\/li>\n<li>Neurolo\u0161ki poreme\u0107aji: op\u0161ta malaksalost, pospanost, poreme\u0107aji \u010dula vida i ukusa<\/li>\n<li>Poreme\u0107aji jetre, citotoksi\u010dnost;<\/li>\n<li>Kardiovaskularni poreme\u0107aji: hipertenzija;<\/li>\n<li>Poreme\u0107aji nervnog sistema: slabost, parestezije, neuropatija.<\/li>\n<li>Hematolo\u0161ki poreme\u0107aji: hipersenzitivna reakcija u vidu ojeda, groznice i vaskulitisa<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2 id=\"kontraindikacije-i-mere-opreza-udruzene-sa-upotrebom-alopurinola\">Kontraindikacije i mere opreza udru\u017eene sa upotrebom Alopurinola<\/h2>\n<p>&nbsp;<\/p>\n<p>Posebna opreznost neophodna je tokom primene ovog leka kod pacijenata sa bubre\u017enim i hepati\u010dnim poreme\u0107ajima. Budu\u0107i na nedostatak nau\u010dnih studija koje bi prou\u010davale efikasnost i sigurnost ovih lekova na razvoj fetusa, primena Alopurinola mo\u017ee biti preporu\u010dena kod osoba \u017eenskog pola tokom trudno\u0107e ii dojenja.\u00a0 Upotreba Alopurinola mo\u017ee tako\u0111e redukovati sposobnost pacijenta za upravljanjem motornog vozila ili drugim ma\u0161inama.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"featured_media":0,"parent":0,"template":"","Example":[1796],"class_list":["post-81759","enciclopedia","type-enciclopedia","status-publish","hentry","enciclopedia_category-aktivni-sastojci"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Alopurinol - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"sr_RS\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Alopurinol - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Hiperurikemija predstavlja klini\u010dko stanje koje se karakteri\u0161e prekomernom koncentracijom mokra\u0107ne kiseline u krvnoj plazmi. Visoke koncentracije tokom du\u017eeg perioda mogu usloviti nastanak ozbiljnijih poreme\u0107aja kao \u0161to su giht i bubre\u017eni kamenovi. Pove\u0107ana produkcija mokra\u0107ne kiseline uslovljena je pove\u0107anom aktivno\u0161\u0107u enzima ksantin oksidaze. 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