{"id":71362,"date":"2017-11-07T20:24:20","date_gmt":"2017-11-07T20:24:20","guid":{"rendered":"http:\/\/humanitasnet-new.local\/malattie\/karcinom-zucnih-vodova\/"},"modified":"2025-01-13T02:57:02","modified_gmt":"2025-01-13T02:57:02","slug":"karcinom-zucnih-vodova","status":"publish","type":"disease","link":"https:\/\/humanitas-net.humweb.webiz.team\/sr\/diseases\/karcinom-zucnih-vodova\/","title":{"rendered":"Karcinom \u017eu\u010dnih vodova"},"content":{"rendered":"

Karcinom \u017eu\u010dnih vodova nastaje u bilijarnim duktusima, vodovima kojima se od jetre \u017eu\u010d prenosi ka tankim crevima. \u017du\u010d se proizvodi u jetri i zadu\u017eena je za razgradnju masti i u\u010destvuje u procesu varenja (digestiju). \u017du\u010d se deponuje u \u017eu\u010dnoj kesi. Najmanji, mnogobrojni \u017eu\u017eni vodovi u jetri formiraju levi\u00a0 i desni \u017eu\u010dni vodu koji napu\u0161ta jetru na njenom donjem uglu. To su takozvani intrahepati\u010dni \u017eu\u010dni vodovi koji se me\u0111usobno spajaju grade\u0107i zajedni\u010dki \u017eu\u010dni vod koji prolazi kroz pankreas (gu\u0161tera\u010du), spaja se sa pankreasnim \u017eu\u010dnim vodovima i izliva u tanko crevo. <\/span><\/p>\n

Uop\u0161teno, na osnovu lokalizacije razlikuju se 3 tipa karcinoma \u017eu\u010dnih vodova:<\/span><\/p>\n

Intrahepati\u010dni karcinom \u017eu\u010dnih vodova \u2013 lokalizovan unutar jetre, mo\u017ee se ponekad zmeniti sa karcinomom jetre s obzirom na intrahepati\u010dnu lokalizaciju<\/span><\/p>\n

Perihilarni (hilarni) karcinom \u017eu\u010dnih vodova \u2013 predstavlja naj\u010de\u0161\u0107i tip, karcinom nastaje u predelu konfluensa levog I desnog hepati\u010dnog spoja duktusa, napu\u0161taju\u0107i pri tom jetru<\/span><\/p>\n

Distalni karcinom bilijarnih \u017eu\u010dnih vodova \u2013 u neposrednoj blizini tankih creva, u predelu zajedni\u010dkog \u017eu\u010dnog kanala<\/span><\/p>\n

Perihilarni i distalni karcinom \u017eu\u010dnih vodova predstavljaju ekstrahepati\u010dne \u017eu\u010dne karcinom.<\/span><\/p>\n

Na osnovu \u0107elijskog tipa, najve\u0107i procenat karcinoma \u017eu\u010dnih vodova su adenokarcinomi koji su porekla iz \u0107elija \u017elezdanog tkiva. Re\u0111i tipovi predstavljaju sarkome, limfome, <\/span><\/p>\n

Ovaj tip karcinoma poznat je kao holangiokarcinom predstavlja retku,ali agresivnu formu karcinoma \u017eu\u010dnih vodova.<\/span><\/p>\n

 <\/p>\n

Simptomi<\/span><\/h2>\n

Simptomi karcinoma \u017eu\u010dnih vodova javlaju se tek kada nastupi opstrukcija \u017eu\u010dnog voda. Nja\u010de\u0161\u0107e se dijagnoza postavlja u uznapredovalom stadijumu bolesti, iako posotji manji procenat rano detektovanih karcinoma \u017eu\u010dnih vodova. Simptomi su slede\u0107i:<\/span><\/p>\n

\u017dutica \u2013 \u017euta prebijenost ko\u017ee i sklera<\/span><\/p>\n

Pruritus (svrab)<\/span><\/p>\n

Promena stolice u vidu svetlije prebojenosti ili poja\u010dane masno\u0107e<\/span><\/p>\n

Tamna prebojenost urina (mokra\u0107e)<\/span><\/p>\n

Bol u predelu trbuha (abdomena), u regiji ispod rebara, karakteristi\u010dno za uznapredovale forme<\/span><\/p>\n

Gubitak na te\u017eini<\/span><\/p>\n

Groznica (povi\u0161ena temperature)<\/span><\/p>\n

Mu\u010dnina i povra\u0107anje<\/span><\/p>\n

Navedeni simptomi mogu se javiti I u drugim oboljenjima kao \u0161to je na primer hepatitis. S toga je lekarski pregled neophodan, kao I dodoatne konsultacije.<\/span><\/p>\n

 <\/p>\n

Uzroci<\/span><\/h2>\n

Ta\u010dan uzrok nastanka karcinoma \u017eu\u010dnih vodova jo\u0161 uvek je nepoznat. Najnovija istra\u017eivanja opisuju zapaljenski process koji izaziva promene unutar same DNA \u0107elija, uzrokuju\u0107i njihov abnormalan rast I deobu pri \u010demu njihov prekomeran broj dovodi do formiranja tumorske mase. Genetska mutacija predstavlja najzna\u010dajniji factor u etiopatogenezi karcinoma. Kod ovog tipa \u0107elija, gen TP53 prona\u0111en je u najve\u0107em broju karcinoma \u017eu\u010dnih vodova.<\/span><\/p>\n

 <\/p>\n

Faktori rizika<\/span><\/h2>\n

Faktori rizika za nastanak karcinoma \u017eu\u010dnih vodova su:<\/span><\/p>\n

Hroni\u010dni zapaljenski (inflamatorni) process izazvan razli\u010diti etiolo\u0161kim faktorima kao \u0161to su o\u017eiljne promene jetrinog tkiva, kamen \u017eu\u010dnih\u00a0 vodova, duktalne ciste, poreme\u0107aji u strukturi duktusa, infekcije jetre metiljima, ciroza jetre, hepatits B ili C virus<\/span><\/p>\n

policisti\u010dno oboljenje jetre<\/span><\/p>\n

Caroli sindrom (dilatacija intrahepati\u010dnih duktusa prisutna na ro\u0111enju)<\/span><\/p>\n

Zapaljenska oboljenja creva, koja uklju\u010duju kronovu bolest I ulcerativni kolitis<\/span><\/p>\n

Starost \u2013 naj\u010de\u0161\u0107e oboljevaju osobe preko 60-70 godina<\/span><\/p>\n

Pozitivna porodi\u010dna anamneza<\/span><\/p>\n

Dijabetes<\/span><\/p>\n

Alkohol \u2013 o\u0161te\u0107enje jetrinog parenhima je predispozicija za nastanak karcinoma<\/span><\/p>\n

Gojaznost \u2013 poreme\u0107aj hormonskog statusa \u010de\u0161\u0107i je kod ovih osoba te su sklonije kamenu u \u017eu\u010di<\/span><\/p>\n

Izlo\u017eenost radioaktivnom zra\u010denju ili azbestoza, radon ili druge hemikalije<\/span><\/p>\n

Pankreatitis<\/span><\/p>\n

Konzumacija duvana<\/span><\/p>\n

Hiv infekcija<\/span><\/p>\n

Komplikacije<\/span><\/p>\n

Naj\u010de\u0161\u0107e komplikacije karcinoma \u017eu\u010dnih vodova su hepati\u010dne ili udaljene metastaze.<\/span><\/p>\n

\u00a0<\/span><\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-71362","disease","type-disease","status-publish","hentry"],"yoast_head":"\nKarcinom \u017eu\u010dnih vodova - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"sr_RS\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Karcinom \u017eu\u010dnih vodova - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Karcinom \u017eu\u010dnih vodova nastaje u bilijarnim duktusima, vodovima kojima se od jetre \u017eu\u010d prenosi ka tankim crevima. \u017du\u010d se proizvodi u jetri i zadu\u017eena je za razgradnju masti i u\u010destvuje u procesu varenja (digestiju). \u017du\u010d se deponuje u \u017eu\u010dnoj kesi. 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