{"id":71349,"date":"2017-11-08T21:11:51","date_gmt":"2017-11-08T21:11:51","guid":{"rendered":"http:\/\/humanitasnet-new.local\/malattie\/primarni-sklerozirajuci-holangitis\/"},"modified":"2025-01-13T02:56:50","modified_gmt":"2025-01-13T02:56:50","slug":"primarni-sklerozirajuci-holangitis","status":"publish","type":"disease","link":"https:\/\/humanitas-net.humweb.webiz.team\/sr\/diseases\/primarni-sklerozirajuci-holangitis\/","title":{"rendered":"Primarni skleroziraju\u0107i holangitis"},"content":{"rendered":"

Primarni skleroziraju\u0107i holangitis je bolest \u017eu\u010dnih puteva koji sprovode \u017eu\u010dne sokove od jetre do dvanaestopala\u010dnog creva. Tokom pojave ovog oboljenja \u017eu\u010dni putevi koji se nalaze u jetri postaju upaljeni, su\u017eavaju se i o\u0161te\u0107uju, \u010dime se spre\u010dava pravilno oticanje \u017eu\u010dnih sokova. Tokom vremena, ovo zapaljenje dovodi do smanjenja dotoka krvi unutar jetre \u0161to dovodi do vr\u0161enja pritiska na venu portu. O\u017eiljci dovode do otvrdnjavanja i su\u017eenja \u017eu\u010dnih puteva i postepeno dovode do ozbiljnog o\u0161te\u0107enja jetre. Kod ve\u0107ine osoba sa PSH, bolest lagano napreduje i mo\u017ee dovesti do gubljenja funkcije jetre, ponavljaju\u0107ih infekcija i tumora. <\/span><\/p>\n

\u00a0<\/span><\/p>\n

Simptomi<\/span><\/h2>\n

U svojoj ranoj fazi, PSH ne daje nikakve simptome. Primarni skleroziraju\u0107i holangitis \u010desto se dijagnostikuje pre same pojave simptoma prilikom rutinske kontrole krvne slike ili tokom rentgen snimanja zbog nekog drugog razloga, tokom \u010dega se uo\u010davaju abnormalnosti na jetri. Stoga, i pre nego \u0161to po\u010dnu da imaju simptome, mnoge osobe se i dalje ose\u0107aju generalno dobro tokom nekoliko godina, i nema pouzdanog na\u010dina da se utvrdi koliko \u0107e brzo ili sporo bolest napredovati. Rani simptomi obuhvataju umor i svrab. Simptomi koji se javljaju paralelno sa napredovanjem bolesti su: <\/span><\/p>\n

Bor u gornjem delu stomaka sa desne strane<\/span><\/p>\n

Groznica<\/span><\/p>\n

Drhtavica<\/span><\/p>\n

No\u0107no znojenje<\/span><\/p>\n

Uve\u0107ana jetra<\/span><\/p>\n

Gubitak te\u017eine<\/span><\/p>\n

\u017dutilo ko\u017ee i beonja\u010da<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Uzroci<\/span><\/h2>\n

Nije jasno \u0161ta dovodi do nastanka PSH. Pomi\u0161ljalo se da je uzrok bolesti autoimune prirode, kada imuni sistem tela napada \u017eu\u010dne puteve u jetri, dovode\u0107i do njihovog zapaljenja i su\u017eenja. Veliki broj osoba sa PSH tako\u0111e ima i upalnu bolest creva, zajedni\u010dki termin koji obuhvata ulcerativni kolitis i Kronovu bolest. U nekim slu\u010dajevima, primarni skleroziraju\u0107i holangitis mo\u017ee biti prisutan godinama pre nego \u0161to se javi upalna bolest creva. I re\u0111e, kod nekih osoba sa primarnim skleroziraju\u0107im holangitisom upalna bolest creva javlja se samo nakon presa\u0111ivanja jetre.<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Faktori rizika<\/span><\/h2>\n

Za slede\u0107e kategorije lica smatra se da su izlo\u017eene pove\u0107anom riziku od dobijanja primarnog skleroziraju\u0107og holangitisa:<\/span><\/p>\n

Osobe starosne dobi od 30 do 50 godina.<\/span><\/p>\n

Osobe mu\u0161kog pola su podlo\u017enije obolevanju.<\/span><\/p>\n

Osobe sa upalnom bolesti creva.<\/span><\/p>\n

Stanovnici Sjedinjenih Ameri\u010dkih Dr\u017eava i Severne Evrope izlo\u017eeniji su riziku od primarnog skleroziraju\u0107eg holangitisa od stanovnika Azije i Ju\u017ene Evrope. \u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Komplikacije<\/span><\/h2>\n

PSH je progresivno oboljenje koje o\u0161te\u0107uje \u017eu\u010dne kanale i smanjuje protok \u017eu\u010di, \u0161to dovodi do portalne hipertenzije, ciroze, i otkazivanja jetre. Komplikacije od primarnog skleroziraju\u0107eg holangitisa mogu biti:<\/span><\/p>\n

Oboljenje jetre i njeno otkazivanje;<\/span><\/p>\n

Ponavljane infekcije;<\/span><\/p>\n

Portalna hipertenzija;<\/span><\/p>\n

Istanjivanje kostiju;<\/span><\/p>\n

Rak \u017eu\u010dnih puteva;<\/span><\/p>\n

Rak debelog creva<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Prevencija<\/span><\/h2>\n

Budu\u0107i da je uzro\u010dnik PSH i dalje nepoznat, izgleda da samim tim ne postoji odgovaraju\u0107a prevencija. Preporu\u010dljivo je da osobe obolele od upalne bolesti creva i njihovi ordiniraju\u0107i lekari imaju na umu povezanost sa PSH, kako bi na vreme reagovali u slu\u010daju da se pojave simptomi koji ukazuju na to oboljenje. <\/span><\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-71349","disease","type-disease","status-publish","hentry"],"yoast_head":"\nPrimarni skleroziraju\u0107i holangitis - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"sr_RS\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Primarni skleroziraju\u0107i holangitis - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Primarni skleroziraju\u0107i holangitis je bolest \u017eu\u010dnih puteva koji sprovode \u017eu\u010dne sokove od jetre do dvanaestopala\u010dnog creva. 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