{"id":71347,"date":"2017-11-08T21:07:38","date_gmt":"2017-11-08T21:07:38","guid":{"rendered":"http:\/\/humanitasnet-new.local\/malattie\/primarna-bilijarna-ciroza\/"},"modified":"2025-01-13T02:56:48","modified_gmt":"2025-01-13T02:56:48","slug":"primarna-bilijarna-ciroza","status":"publish","type":"disease","link":"https:\/\/humanitas-net.humweb.webiz.team\/sr\/diseases\/primarna-bilijarna-ciroza\/","title":{"rendered":"Primarna bilijarna ciroza"},"content":{"rendered":"

Primarna bilijarna ciroza (PBC) je dugotrajno autoimuno oboljenje jetre kod koga dolazi do o\u0161te\u0107enja \u017eu\u010dnih puteva unutar jetre, \u0161to postepeno dovodi do nagomilavanja \u0161tetnih materija u jetri, koje mo\u017ee da dovede do uru\u0161avanja i na kraju trajnog o\u0161te\u0107enja tkiva jetre. <\/span><\/p>\n

\u00a0<\/span><\/p>\n

Simptomi<\/span><\/h2>\n

Iako neke osobe sa primarnom bilijarnom cirozom \u010dak nekoliko godina nakon uspostavljanja dijagnoze nemaju nikakve simptome, postoje i one koje imaju \u010ditav niz znakova i simptoma ovog oboljenja. Uobi\u010dajeni rani simptomi ubrajaju umor, svrab ko\u017ee, suva usta i o\u010di. Me\u0111u simptome koji se javljaju kasnije spadaju: <\/span><\/p>\n

Bol u gornjem desnom delu stomaka;<\/span><\/p>\n

Bol u kostima, mi\u0161i\u0107ima i zglobovima;<\/span><\/p>\n

\u017dutilo ko\u017ee i beonja\u010da;<\/span><\/p>\n

Taman ten koji nije posledica izlaganja suncu;<\/span><\/p>\n

Ote\u010dena stopala i \u010dlanci;<\/span><\/p>\n

Nakupljanje te\u010dnosti u abdomen usled smanjene funkcije jetre;<\/span><\/p>\n

Nagomilavanje masnih naslaga na ko\u017ei oko o\u010diju, na o\u010dnim kapcima, ili na dlanovima, tabanima, laktovima ili kolenima;<\/span><\/p>\n

Slabe i krhke kosti;<\/span><\/p>\n

Povi\u0161eni holesterol;<\/span><\/p>\n

Dijareja koja mo\u017ee biti masna;<\/span><\/p>\n

Smanjena funckija \u0161titne \u017elezde<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Uzroci<\/span><\/h2>\n

Nije poznat ta\u010dan uzrok PBC, iako postoji uvre\u017eeno mi\u0161ljenje da se javlja kao posledica problema u imunom sistemu. Ve\u0107ina stru\u010dnjaka smatra da je primarna bilijarna ciroza autoimuno oboljenje u kojem telo napada svoje sopstvene \u0107elije. U tim slu\u010dajevima, imuni sistem u \u017eu\u010dne puteve \u0161alje specijalizovane \u0107elije koje obi\u010dno slu\u017ee za ubijanje bakterija i virusa. Na \u017eu\u010dnim putevima se postepeno stvaraju o\u017eiljci i na taj na\u010din se spe\u010dava oticanje \u017eu\u010di iz jetre. Ovo o\u0161te\u0107enje vremenom mo\u017ee dovesti do gubitka funkcije jetre, \u0161to mo\u017ee imati fatalan ishod. <\/span><\/p>\n

S druge strane, neki stru\u010dnjaci veruju da bolest nastaje kombinacijom genetskih faktora i uticaja sredine. \u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Faktori rizika<\/span><\/h2>\n

Smatra se da su slede\u0107e kategorije izlo\u017eene ve\u0107em riziku od dobijanja PBC-a: <\/span><\/p>\n

Osobe \u017eenskog pola <\/span><\/p>\n

Osobe starosne dobi izme\u0111u 30 i 60 godina.<\/span><\/p>\n

Osobe \u010diji su \u010dlanovi porodice imali ovo oboljenje <\/span><\/p>\n

Nau\u010dnici smatraju da genetski faktori zajedno sa uticajima sredine dovode do nastanka primarne bilijarne ciroze. U uticaje sredine spadaju infekcije, pu\u0161enje i toksini koji se nalaze u na\u0161em okru\u017eenju.<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Komplikacije<\/span><\/h2>\n

Komplikacije primarne bilijarne ciroze se razvijaju srazmerno opadanju funkcije jetre. Kako o\u0161te\u0107enje jetre napreduje, kod osoba sa primarnom bilijarnom cirozom mogu da se razviju brojne komplikacije i ozbiljni problemi, uklju\u010duju\u0107i: <\/span><\/p>\n

Cirozu;<\/span><\/p>\n

Portalnu hipertenziju;<\/span><\/p>\n

Uve\u0107anje slezine;<\/span><\/p>\n

Edem;<\/span><\/p>\n

Lako krvarenje i pojava modrica;<\/span><\/p>\n

Kamen u \u017eu\u010dnoj kesi i \u017eu\u010dnim putevima;<\/span><\/p>\n

Pro\u0161irene vene;<\/span><\/p>\n

Rak jetre;<\/span><\/p>\n

Osteoporozu;<\/span><\/p>\n

Nedostatak vitamina A, D, E i K;<\/span><\/p>\n

Smanjena mentalna funkcija.<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Prevencija<\/span><\/h2>\n

Budu\u0107i da sam uzrok bolesti nije poznat, nije mogu\u0107e spre\u010diti nastanak primarne bilijarne ciroze. Me\u0111utim, lekovi mogu da dovedu do usporenja napredovanja bolesti i da simptome dr\u017ee pod kontrolom. Ukoliko se kod osobe javi PBC, trebalo bi u\u010diniti sve kako bi se spre\u010dilo dalje potencijalno o\u0161te\u0107enje. Pod tim se podrazumeva ograni\u010denje unosa alkohola, kao i \u00a0izbegavanje upotrebe lekova koji sadr\u017ee acetaminofen i agense za sni\u017eenje holesterola. <\/span><\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-71347","disease","type-disease","status-publish","hentry"],"yoast_head":"\nPrimarna bilijarna ciroza - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"sr_RS\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Primarna bilijarna ciroza - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Primarna bilijarna ciroza (PBC) je dugotrajno autoimuno oboljenje jetre kod koga dolazi do o\u0161te\u0107enja \u017eu\u010dnih puteva unutar jetre, \u0161to postepeno dovodi do nagomilavanja \u0161tetnih materija u jetri, koje mo\u017ee da dovede do uru\u0161avanja i na kraju trajnog o\u0161te\u0107enja tkiva jetre. \u00a0 Simptomi Iako neke osobe sa primarnom bilijarnom cirozom \u010dak nekoliko godina nakon uspostavljanja dijagnoze […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/humanitas-net.humweb.webiz.team\/sr\/diseases\/primarna-bilijarna-ciroza\/\" \/>\n<meta property=\"og:site_name\" content=\"Humanitas.net\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/HumanitasInternational\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-13T02:56:48+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@humanitasmilano\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/humanitas-net.humweb.webiz.team\/sr\/diseases\/primarna-bilijarna-ciroza\/\",\"url\":\"https:\/\/humanitas-net.humweb.webiz.team\/sr\/diseases\/primarna-bilijarna-ciroza\/\",\"name\":\"Primarna bilijarna ciroza - 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