{"id":71338,"date":"2017-11-08T19:59:19","date_gmt":"2017-11-08T19:59:19","guid":{"rendered":"http:\/\/humanitasnet-new.local\/malattie\/poems-sindrom\/"},"modified":"2025-01-13T02:56:41","modified_gmt":"2025-01-13T02:56:41","slug":"poems-sindrom","status":"publish","type":"disease","link":"https:\/\/humanitas-net.humweb.webiz.team\/sr\/diseases\/poems-sindrom\/","title":{"rendered":"POEMS Sindrom"},"content":{"rendered":"

POEMS sindrom, tako\u0111e poznat pod imenom Crow\u2013Fukase sindrom, Takatsuki bolest, ili PEP sindrom, je redak poreme\u0107aj krvi koji o\u0161te\u0107uje nerve pacijenta i poga\u0111a mnoge druge delove tela. <\/span>Definisan je kao kombinacija proliferativnog poreme\u0107aja plazma \u0107elija, polineuropatije, i poga\u0111a mnoge sisteme organa. <\/span><\/p>\n

POEMS sindrom mo\u017ee pogre\u0161no da se dijagnostikuje zato \u0161to se njegovi znaci i simptomi zbog sli\u010dnosti dovode u vezu sa nekim drugim poreme\u0107ajima. POEMS sindrom veoma brzo napreduje i mo\u017ee biti opasan po \u017eivot, zbog \u010dega je rano uspostavljanje dijagnoze veoma zna\u010dajno. \u00a0<\/span><\/p>\n

\u00a0<\/span><\/p>\n

Simptomi<\/span><\/h2>\n

Sam termin “POEMS” je akronim izveden od slede\u0107ih znakova i simptoma: <\/span><\/p>\n

Polineuropatija. Pojava koja defini\u0161e oboljenje, a koja je obi\u010dno simetri\u010dna i distalna. Kod nje postoji kombinacija demijelinacije i o\u0161te\u0107enja aksona, a njome su obuhva\u0107eni senzorni, motorni i autonomni nervi. Tipi\u010dni simptomi su stoga utrnulost, golicanje i slabost stopala, \u0161to se kasnije pro\u0161iruje i na noge i ruke. Bol nije uobi\u010dajen, ali slabost vremenom mo\u017ee postati ozbiljna i dovodi do onesposobljavanja. Autonomi\u010dna neuropatija mo\u017ee da dovede do prekomernog znojenja i erektilne disfunkcije. <\/span><\/p>\n

Organomegalija. Karakteri\u0161e se uve\u0107anom slezinom, jetrom i limfnim \u010dvorovima. \u00a0<\/span><\/p>\n

Endokrinopatija. Abnormalni nivoi hormona koji mogu dovesti do oslabljene aktivnosti \u0161titne \u017elezde, dijabetesa, seksualnih problema, umora, oticanja ekstremiteta i problema sa metabolizmom i drugim osnovnim funkcijama. \u00a0<\/span><\/p>\n

Monoklonski plazma-proliferativni poreme\u0107aj. To je druga pojava kojom se defni\u0161e ovaj sindrom i predstavlja naj\u010de\u0161\u0107i proliferativni poreme\u0107aj plazma \u0107elija koji je povezan sa POEMS sindromom, i koji je prisutan u vi\u0161e od polovine svih slu\u010dajeva oboljenja. Karakteristika ovog poreme\u0107aja su abnormalne \u0107elije ko\u0161tane sr\u017ei koje proizvode monoklonski protein koji se mo\u017ee na\u0107i u krvotoku. <\/span><\/p>\n

Promene na ko\u017ei. \u010citav niz razli\u010ditih problema sa ko\u017eom bele\u017ei se u vezi sa POEMS sindromom. Naj\u010de\u0161\u0107i od njih je nespecifi\u010dna hiperpigmentacija, kada nokti na prstima mogu biti bati\u010dasti ili beli. Osim toga, ko\u017ea pacijenta mo\u017ee biti vi\u0161e prebojena nego \u0161to je to uobi\u010dajeno; mo\u017ee se javiti i istanjivanje ko\u017ee; prevelika dlakavost i pojava malja na neobi\u010dnim mestima; angiom ko\u017ee ili hemangiom, a mogu postojati promene sli\u010dne sklerodermiji. <\/span><\/p>\n

Me\u0111u ostalim simptomima mogu se na\u0107i i edem opti\u010dkog diska, plu\u0107ne bolesti koje se javljaju u te\u017eim fazama bolesti i koje poga\u0111aju plu\u0107a; edemi (koji predstavljaju curenje te\u010dnosti u tkiva) i hormonalni problemi poput: endokrinopatije, dijabetesa tipa 2, hipotiroidizma i adrenalne insuficijencija. <\/span><\/p>\n

\u00a0<\/span><\/p>\n

Faktori rizika<\/span><\/h2>\n

Obi\u010dno POEMS sindrom po\u010dinje da se javlja kod osoba srednjih godina. Prose\u010dna starost kada se javlja ovo oboljenje je oko 50. godine \u017eivota. Osim toga, POEMS sindrom skoro dva puta vi\u0161e poga\u0111a mu\u0161karce nego \u017eene. <\/span><\/p>\n

\u00a0<\/span><\/p>\n

Komplikacije<\/span><\/h2>\n

Ukoliko se POEMS sindrom ne le\u010di, on \u0107e verovatno napredovati i \u010desto mo\u017ee biti fatalan za pacijenta, sa samo 60% obolelih koji su ostali \u017eivi 5 godina od pojave oboljenja. Me\u0111utim, simptomi mogu da se pobolj\u0161aju ukoliko se poreme\u0107aj krvi uspe\u0161no le\u010di. <\/span><\/p>\n

Neuobi\u010dajene pojave ili komplikacije su:<\/span><\/p>\n

Respiratorna \u2013 plu\u0107na hipertenzija, restriktivna bolest plu\u0107a.<\/span><\/p>\n

Tromboza \u2013 arterijska ili venska.<\/span><\/p>\n

Smanjena funkcija bubrega.<\/span><\/p>\n

Sr\u010dana insuficijencija.<\/span><\/p>\n

Sindrom sli\u010dan prevelikoj popustljivosti kapilara<\/span><\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-71338","disease","type-disease","status-publish","hentry"],"yoast_head":"\nPOEMS Sindrom - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"sr_RS\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"POEMS Sindrom - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"POEMS sindrom, tako\u0111e poznat pod imenom Crow\u2013Fukase sindrom, Takatsuki bolest, ili PEP sindrom, je redak poreme\u0107aj krvi koji o\u0161te\u0107uje nerve pacijenta i poga\u0111a mnoge druge delove tela. Definisan je kao kombinacija proliferativnog poreme\u0107aja plazma \u0107elija, polineuropatije, i poga\u0111a mnoge sisteme organa. 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