{"id":81849,"date":"2018-06-29T10:25:25","date_gmt":"2018-06-29T10:25:25","guid":{"rendered":"http:\/\/humanitasnet-new.local\/enciclopedia\/acidul-ethacrynic-2\/"},"modified":"2018-06-29T10:25:25","modified_gmt":"2018-06-29T10:25:25","slug":"acidul-ethacrynic-2","status":"publish","type":"enciclopedia","link":"https:\/\/humanitas-net.humweb.webiz.team\/ro\/wiki\/acidul-ethacrynic-2\/","title":{"rendered":"Acidul ethacrynic"},"content":{"rendered":"

Acidul ethacrynic este un diuretic cu o ac\u021biune inhibitorie semnificativ\u0103 de reabsorb\u021bie a electroli\u021bilor, \u00een special la nivelul membrelor ascendente ale lui Henle. Se administreaz\u0103 pe cale oral\u0103 sau intravenoas\u0103 pacien\u021bilor cu forme edematoase severe care nu r\u0103spund adecvat la alte diuretice.<\/p>\n

Mecanismul de ac\u021biune este \u00eenc\u0103 neclar, dar se consider\u0103 c\u0103 ac\u021bioneaz\u0103 prin inhibarea reabsorb\u021biei ionilor de sodiu (Na +) de-a lungul nefronului, prin reac\u021bia cu grup\u0103rile sulfhidril ale proteinelor celulare.<\/p>\n

Ce este acidul ethacrynic?<\/h2>\n

Obiectivul principal al acidului ethacrynic este, ca toate diureticele, de a \u00eencuraja producerea \u0219i eliminarea urinei. \u00cen special, acest medicament este utilizat \u00een special la pacien\u021bii cu forme edematoase severe care nu r\u0103spund adecvat tratamentului cu alte diuretice.<\/p>\n

Cum ar trebui s\u0103 fie luat\u0103 acidul ethacrynic?<\/h2>\n

Acidul etacrinic este disponibil at\u00e2t pentru administrarea oral\u0103, c\u00e2t \u0219i intravenoas\u0103.<\/p>\n

Efecte secundare asociate cu acidul ethacrynic<\/p>\n

Principalele efecte adverse recunoscute care rezult\u0103 din utilizarea acestui medicament includ:
\n\u2022 Dezechilibru electrolitic (deshidratare) caracterizat prin: grea\u021b\u0103 sau v\u0103rs\u0103turi, sl\u0103biciune sau oboseal\u0103, hipotensiune, sete, gur\u0103 uscat\u0103, crampe musculare, modific\u0103ri ale dispozi\u021biei, confuzie mental\u0103, hiponatremie, hipercalcemie, hipoglicemie, hiperuricemie;
\n\u2022 discrasii de s\u00e2nge (stare anormal\u0103 sau tulburare a componentelor s\u00e2ngelui);
\n\u2022 Tulbur\u0103ri gastro-intestinale: grea\u021b\u0103, v\u0103rs\u0103turi, disfagie, dureri abdominale;
\n\u2022 Tulbur\u0103ri sistemice: cefalee, febr\u0103;
\n\u2022 Tulbur\u0103ri de rinichi
\n\u2022 Tulbur\u0103ri ale sistemului vestibular: tinitus, pierderea auzului, vertij<\/p>\n

Contraindica\u021bii \u0219i avertismente asociate cu utilizarea acidului ethacrynic<\/h2>\n

Acidul ethacrynic este contraindicat la femeile gravide sau care al\u0103pteaz\u0103 \u0219i la copiii cu v\u00e2rsta sub doi ani. Mai mult, acest medicament trebuie, de asemenea, administrat cu pruden\u021b\u0103 la pacien\u021bii cu ciroz\u0103 hepatic\u0103 avansat\u0103. Similar altor diuretice, acidul ethacrynic poate duce la o com\u0103 hepatic\u0103.<\/p>\n

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