{"id":70840,"date":"2017-05-22T14:47:54","date_gmt":"2017-05-22T14:47:54","guid":{"rendered":"http:\/\/humanitasnet-new.local\/malattie\/fibroza-sistemica-nefrogena\/"},"modified":"2025-01-13T02:49:34","modified_gmt":"2025-01-13T02:49:34","slug":"fibroza-sistemica-nefrogena","status":"publish","type":"disease","link":"https:\/\/humanitas-net.humweb.webiz.team\/ro\/diseases\/fibroza-sistemica-nefrogena\/","title":{"rendered":"Fibroz\u0103 sistemic\u0103 nefrogen\u0103"},"content":{"rendered":"

Defini\u021bie<\/h2>\n

Fibroza sistemic\u0103 nefrogen\u0103 (NSF), denumit\u0103 \u0219i dermopatie fibrozant\u0103 nefrogen\u0103, este o boal\u0103 rar\u0103 a fibrozei pielii, articula\u021biilor, ochilor \u0219i organelor interne. Afecteaz\u0103 de obicei oamenii care au insuficien\u021b\u0103 renal\u0103 acut\u0103 sau oamenii care fac dializ\u0103. Exist\u0103 unele semne care sugereaz\u0103 c\u0103 fibroza sistemic\u0103 nefrogen\u0103 este legat\u0103 de expunerea la gadolinium (sau agen\u021bi de contrast pentru RMN pe baz\u0103 de gadolinium) folosit în mod frecvent la pacien\u021bii cu insuficien\u021b\u0103 renal\u0103 sever\u0103. Boala se manifest\u0103 prin buc\u0103\u021bi mari r\u0103spândite de piele sub\u021bire sau în\u0103sprit\u0103. Boala poate afecta \u0219i organele interne, cum ar fi inima, rinichii \u0219i pl\u0103mânii provocând scurtarea mu\u0219chilor \u0219i tendoanelor din articula\u021bii sau contrac\u021bia articula\u021biilor.<\/p>\n

 <\/p>\n

Simptome<\/h2>\n

Când un om este afectat de fibroza sistemic\u0103 nefrogen\u0103, acestuia îi apar p\u0103r\u021bi mari de piele în\u0103sprit\u0103 cu noduli \u0219i pl\u0103gi fibriotice. Boala poate s\u0103 duc\u0103 \u0219i la rigiditatea musculaturii care provoac\u0103 durerea articula\u021biilor \u0219i reduce mobilitatea articula\u021biei. Cea mai sever\u0103 form\u0103 de NSF este fibroza sistemic\u0103 sever\u0103 care afecteaz\u0103 organele interne.  <\/p>\n

 <\/p>\n

Cauze<\/h2>\n

Nu se \u0219tie ce provoac\u0103 mai exact fibroza sistemic\u0103 nefrogen\u0103. Totu\u0219i, în aproape toate cazurile exist\u0103 un tip de disfunc\u021bie a rinichiului prezent\u0103. Aproape 90% din pacien\u021bii care experimenteaz\u0103 NSF-ul au avut o boal\u0103 de rinichi în stadiu final \u0219i au primit hemodializ\u0103 sau dializ\u0103 peritoneal\u0103. În restul cazurilor, oamenii au avut boli cronice de rinichi sau afectarea serioas\u0103 a rinichiului. Pare c\u0103 o boal\u0103 de baz\u0103 a rinichiului este necesar\u0103 pentru ca NSF-ul s\u0103 apar\u0103. Totu\u0219i, nu fiecare pacient cu un tip de boal\u0103 de rinichi dezvolt\u0103 fibroza sistemic\u0103 nefrogen\u0103, astfel c\u0103 se presupune c\u0103 exist\u0103 un declan\u0219ator pentru ca boala s\u0103 apar\u0103. Declan\u0219atorul exact nu este familiar, dar agentul de contrast gadolinium din rezonan\u021ba magnetic\u0103 este considerat a fi principalul suspect.<\/p>\n

 <\/p>\n

Factori de risc<\/h2>\n

Factorii care pot cre\u0219te riscul apari\u021biei fibrozei sistemice nefrogene pot fi asocia\u021bi cu o boal\u0103 de baz\u0103 a rinichiului sau scan\u0103rile RMN. Unii factori de risc includ urm\u0103toarele:<\/p>\n

Expunerea la gadolinium<\/p>\n

Starea proinflamatorie<\/p>\n

Infec\u021bia (pneumonia, osteomielita, septicemie)<\/p>\n

Evenimente ischemice<\/p>\n

R\u0103nirea membrelor<\/p>\n

R\u0103nirea \u021besuturilor<\/p>\n

Caracterul v\u0103t\u0103m\u0103tor<\/p>\n

Opera\u021bia recent\u0103<\/p>\n

Tromboza<\/p>\n

Afec\u021biunea renal\u0103<\/p>\n

Insuficien\u021ba renal\u0103 sever\u0103<\/p>\n

Insuficien\u021ba renal\u0103 cronic\u0103<\/p>\n

Hemodializa<\/p>\n

Dializa peritoneal\u0103<\/p>\n

 <\/p>\n

Tratament<\/h2>\n

Nu exist\u0103 un tratament specific pentru fibroza sistemic\u0103 nefrotic\u0103. Totu\u0219i, cea mai bun\u0103 op\u021biune pare s\u0103 fie terapia care a fost proiectat\u0103 pentru a îmbun\u0103t\u0103\u021bi func\u021bia renal\u0103. Încetine\u0219te \u0219i inverseaz\u0103 efectele NSF. Terapia fizic\u0103 este recomandat\u0103 \u0219i pentru a îmbun\u0103t\u0103\u021bi mobilitatea articula\u021biilor în cazul rigidit\u0103\u021bii articula\u021biei.<\/p>\n

Exist\u0103 mai multe abord\u0103ri pentru a trata fibroza sistemic\u0103 nefrogen\u0103 care prezint\u0103 diferite rezultate de succes.<\/p>\n

Unele din aceste abord\u0103ri sunt:<\/p>\n

·         Transplantul renal<\/p>\n

·         Plasmafereza<\/p>\n

·         Fotoforeza extracorporal\u0103<\/p>\n

·         Terapia cu tiosulfat de sodiu<\/p>\n

·         Terapia cu mesilat de imatinib <\/p>\n

·         Terapia cu pentoxifilin<\/p>\n

·         Terapia intravenoas\u0103 cu imunoglobulin\u0103<\/p>\n

·         Terapia cu steroizi<\/p>\n

·         Terapia cu ciclofosfamid\u0103 <\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-70840","disease","type-disease","status-publish","hentry"],"yoast_head":"\nFibroz\u0103 sistemic\u0103 nefrogen\u0103 - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fibroz\u0103 sistemic\u0103 nefrogen\u0103 - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Defini\u021bie Fibroza sistemic\u0103 nefrogen\u0103 (NSF), denumit\u0103 \u0219i dermopatie fibrozant\u0103 nefrogen\u0103, este o boal\u0103 rar\u0103 a fibrozei pielii, articula\u021biilor, ochilor \u0219i organelor interne. Afecteaz\u0103 de obicei oamenii care au insuficien\u021b\u0103 renal\u0103 acut\u0103 sau oamenii care fac dializ\u0103. 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