{"id":70744,"date":"2017-03-30T15:58:51","date_gmt":"2017-03-30T15:58:51","guid":{"rendered":"http:\/\/humanitasnet-new.local\/malattie\/ciroza-biliara-primara\/"},"modified":"2025-01-13T02:48:15","modified_gmt":"2025-01-13T02:48:15","slug":"ciroza-biliara-primara","status":"publish","type":"disease","link":"https:\/\/humanitas-net.humweb.webiz.team\/ro\/diseases\/ciroza-biliara-primara\/","title":{"rendered":"Ciroza biliar\u0103 primar\u0103"},"content":{"rendered":"

Ciroza biliar\u0103 primar\u0103<\/strong><\/h2>\n

 <\/p>\n

 <\/p>\n

Ciroza biliar\u0103 primar\u0103 (CBP) este o boal\u0103 hepatic\u0103 autoimun\u0103 pe termen lung, în care canalele biliare din ficat se deterioreaz\u0103, ceea ce duce treptat la o acumulare de substan\u021be nocive în ficat, care pot provoca leziuni \u0219i, eventual, duce la cicatrici ireversibile ale \u021besutului.<\/p>\n

 <\/p>\n

Simptome<\/strong><\/h2>\n

Cu toate c\u0103 unii oameni cu ciroz\u0103 biliar\u0103 primar\u0103 r\u0103mân f\u0103r\u0103 simptome de ani de zile dup\u0103 ce au fost diagnosticate, al\u021bii experimenteaz\u0103 o serie de semne \u0219i simptome. Simptomele precoce comune includ oboseala, mânc\u0103rimi ale pielii \u0219i uscarea ochilor \u0219i a gurii. Simptomele ulterioare pot include:<\/p>\n

    \n
  • durere în partea din dreapta sus a abdomenului;<\/li>\n
  • osoase, dureri musculare sau articulare;<\/li>\n
  • îng\u0103lbenirea pielii \u0219i a ochilor;<\/li>\n
  • înnegrire a pielii, care nu este legat\u0103 de expunerea la soare;<\/li>\n
  • picioare \u0219i glezne tumefiate;<\/li>\n
  • acumularea de lichid în abdomen din cauza insuficien\u021bei hepatice;<\/li>\n
  • depozite de gr\u0103sime pe pielea din jurul ochilor, a pleoapelor, sau cute pe palme, t\u0103lpi, coate sau genunchi;<\/li>\n
  • oase slabe \u0219i fragile;<\/li>\n
  • valori crescute ale colesterolului;<\/li>\n
  • diaree;<\/li>\n
  • tiroid\u0103.<\/li>\n<\/ul>\n

     <\/p>\n

    Cauze<\/strong><\/h2>\n

    Cauza exact\u0103 a CBP nu este cunoscut\u0103, de\u0219i se crede pe scar\u0103 larg\u0103 pare a fi rezultatul unei probleme a sistemului imunitar. Cei mai mul\u021bi exper\u021bi consider\u0103 ciroza biliar\u0103 primar\u0103 o boal\u0103 autoimun\u0103 în care organismul atac\u0103 propriile celule. În aceste cazuri, sistemul imunitar trimite celule specializate care ucid de obicei, bacteriile \u0219i virusurile din canalele biliare. \u021aesuturile devin, treptat, pline de cicatrici \u0219i perturb\u0103 fluxul bilei din ficat. Acest lucru poate provoca daune ale ficatului, acesta urmând s\u0103-\u0219i piard\u0103 func\u021bia sa, care este poten\u021bial fatal\u0103.<\/p>\n

    Al\u021bi exper\u021bi cred c\u0103 aceasta este declan\u0219at\u0103 de o combina\u021bie de factori genetici \u0219i de mediu.<\/p>\n

     <\/p>\n

    Factori de risc<\/strong><\/h2>\n

    Urm\u0103toarele categorii sunt considerate a fi expuse unui risc mai mare de a suferi de CBP:<\/p>\n

      \n
    • femei<\/li>\n
    • oamenii cu vârsta cuprins\u0103 între 30 \u0219i 60 de ani<\/li>\n
    • persoanele ale c\u0103ror membri de familie au avut boala<\/li>\n<\/ul>\n

      Cercet\u0103torii consider\u0103 c\u0103 factorii genetici, atunci când sunt combina\u021bi cu factorii de mediu, declan\u0219eaz\u0103 ciroza biliar\u0103 primar\u0103. ace\u0219ti factori de mediu pot include infec\u021biile, fumatul \u0219i toxinele din mediu.<\/p>\n

       <\/p>\n

      Complica\u0163ii<\/strong><\/h2>\n

      Complica\u021biile ciroza biliar\u0103 primar\u0103 dezvolt\u0103 abilitatea ficatului de a-\u0219i diminua func\u021biile. Dup\u0103 ce leziunile hepatice progreseaz\u0103, persoanele cu ciroza biliar\u0103 primar\u0103 pot dezvolta o serie de complica\u021bii \u0219i probleme grave, inclusiv:<\/p>\n

        \n
      • ciroz\u0103;<\/li>\n
      • hipertensiune portal\u0103;<\/li>\n
      • splina marit\u0103;<\/li>\n
      • edem;<\/li>\n
      • învine\u021bire sau sângerare u\u0219oar\u0103;<\/li>\n
      • calculi biliari \u0219i pietre biliare;<\/li>\n
      • vene m\u0103rite;<\/li>\n
      • cancer de ficat;<\/li>\n
      • osteoporoz\u0103;<\/li>\n
      • deficien\u021be ale vitaminelor A, D, E \u0219i K;<\/li>\n
      • sc\u0103derea func\u021biei mentale.<\/li>\n<\/ul>\n

         <\/p>\n

        Profilaxie<\/strong><\/h2>\n

        Deoarece cauza bolii nu este cunoscut\u0103, nu este posibil\u0103 prevenirea CBP. Cu toate acestea, medicamentele pot fi în m\u0103sura de a încetini progresia bolii \u0219i controlul simptomelor. În cazul în care o persoan\u0103 dezvolt\u0103 CBP, ar trebui s\u0103 se fac\u0103 toate încerc\u0103rile de a preveni în continuare poten\u021bialul de deteriorare. Aceasta poate include limitarea consumului de alcool, evitarea utiliz\u0103rii de medicamente care con\u021bin acetaminofen \u0219i agen\u021bi de reducere a colesterolului.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-70744","disease","type-disease","status-publish","hentry"],"yoast_head":"\nCiroza biliar\u0103 primar\u0103 - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Ciroza biliar\u0103 primar\u0103 - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Ciroza biliar\u0103 primar\u0103     Ciroza biliar\u0103 primar\u0103 (CBP) este o boal\u0103 hepatic\u0103 autoimun\u0103 pe termen lung, în care canalele biliare din ficat se deterioreaz\u0103, ceea ce duce treptat la o acumulare de substan\u021be nocive în ficat, care pot provoca leziuni \u0219i, eventual, duce la cicatrici ireversibile ale \u021besutului.   Simptome Cu toate c\u0103 unii […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/humanitas-net.humweb.webiz.team\/ro\/diseases\/ciroza-biliara-primara\/\" \/>\n<meta property=\"og:site_name\" content=\"Humanitas.net\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/HumanitasInternational\/\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-13T02:48:15+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@humanitasmilano\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/humanitas-net.humweb.webiz.team\/ro\/diseases\/ciroza-biliara-primara\/\",\"url\":\"https:\/\/humanitas-net.humweb.webiz.team\/ro\/diseases\/ciroza-biliara-primara\/\",\"name\":\"Ciroza biliar\u0103 primar\u0103 - 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