{"id":70449,"date":"2017-03-30T13:10:17","date_gmt":"2017-03-30T13:10:17","guid":{"rendered":"http:\/\/humanitasnet-new.local\/malattie\/sindromul-poems\/"},"modified":"2025-01-13T02:44:05","modified_gmt":"2025-01-13T02:44:05","slug":"sindromul-poems","status":"publish","type":"disease","link":"https:\/\/humanitas-net.humweb.webiz.team\/ro\/diseases\/sindromul-poems\/","title":{"rendered":"Sindromul POEMS"},"content":{"rendered":"

Sindromul POEMS<\/h2>\n

 <\/p>\n

Sindromul POEMS, care este, de asemenea, cunoscut sub numele de sindromul Crow-Fukase, boala Takatsuki, sau sindromul PEP, este o afec\u0163iune rar\u0103 de sânge care lezeaz\u0103 nervii \u0219i afecteaz\u0103 multe alte p\u0103r\u021bi ale corpului. Acesta este definit ca o combina\u021bie de proliferare a plasmocitelor, polineuropatie, \u0219i efectele asupra multor alte sisteme de organe.<\/p>\n

Sindromul POEMS poate fi diagnosticat gre\u0219it, deoarece semnele si simptomele imit\u0103 pe cele ale altor tulbur\u0103ri. Sindromul POEMS progreseaz\u0103 rapid \u0219i poate pune via\u021ba în pericol, diagnosticul pus devreme este important.<\/p>\n

 <\/p>\n

Simptome<\/h2>\n

Termenul "POEMS" este un acronim care deriv\u0103 din urm\u0103toarele semne \u0219i simptome:<\/p>\n

Polineuropatie. Este o caracteristic\u0103 definitorie \u0219i este de obicei simetric\u0103 \u0219i distal\u0103. Este o combina\u021bie de demielinizare \u0219i leziune axonal\u0103, \u0219i senzorial\u0103, motorie \u015fi neuronii autonomi sunt afecta\u021bi. Simptomele tipice sunt, prin urmare, amor\u021beal\u0103, furnic\u0103turi \u0219i sl\u0103biciune la nivelul picioarelor, care afecteaz\u0103 mai târziu picioarele \u0219i mâinile. Durerea este neobi\u0219nuit\u0103, dar sl\u0103biciunea poate deveni în cele din urm\u0103 sever\u0103. Neuropatia autonom\u0103 poate provoca transpira\u021bie excesiv\u0103 \u0219i disfunc\u021bii erectile.<\/p>\n

Organomegalie. Acesta este caracterizat printr-o m\u0103rirea a splinei, ficatului sau a ganglionilor limfatici.<\/p>\n

Endocrinopatie. Nivelurile anormale de hormoni, care pot duce la hipotiroidie, diabet, probleme sexuale, oboseal\u0103, umflarea membrelor \u015fi probleme cu metabolismul \u0219i alte func\u021bii esen\u021biale.<\/p>\n

Proliferare monoclonal\u0103. Estea doua caracteristic\u0103 definitorie \u0219i cea mai comun\u0103 tulburare proliferativ\u0103 a plasmocitelor cel mai frecvent asociat\u0103 cu sindromul POEMS, prezent\u0103 în mai mult de jum\u0103tate din toate cazurile. Caracteristica acestor cazuri sunt celulele anormale ale maduvei osoase care produc o protein\u0103 monoclonal\u0103, ce poate fi g\u0103sit\u0103 în fluxul sanguin.<\/p>\n

Modific\u0103ri ale pielii. O varietate foarte larg\u0103 de probleme ale pielii au fost raportate în asociere cu sindromul POEMS. Cele mai frecvente sunt hiperpigmentarea non-specific\u0103, atunci când unghiile pot fi hipocratice sau albe. În plus, pacientul poate avea hiperpigmentare a pielii; pot exista îngro\u0219area pielii; p\u0103rul în exces sau p\u0103r în locuri neobi\u0219nuite; angiom al pielii sau hemangioame sau pot exista modific\u0103ri care amintesc de sclerodermie.<\/p>\n

Alte simptome includ edem papilar, boli pulmonare, care apar în stadii mai severe ale bolii \u0219i afecteaz\u0103 pl\u0103mânii; edeme (care sunt o acumulare de lichid în \u0163esuturi) si probleme hormonale, cum ar fi: endocrinopatie, diabet de tip 2, hipotiroidie \u0219i insuficien\u021b\u0103 suprarenal\u0103;<\/p>\n

 <\/p>\n

Factori de risc<\/h2>\n

De obicei, sindromul POEMS apare la vârsta mijlocie. Vârsta medie de debut este de 50 de ani. În afar\u0103 de aceasta, sindromul PEOMS afecteaza de dou\u0103 ori mai mul\u0163i b\u0103rba\u0163i ca femei.<\/p>\n

 <\/p>\n

Complica\u0163ii<\/h2>\n

În cazul în care sindromul POEMS este lasat netratat, va progresa cel mai probabil \u0219i poate fi fatal pentru pacient, cu doar 60% dintre suferinzi r\u0103ma\u0219i în via\u021b\u0103 la cinci ani de la debut. Cu toate acestea, simptomele pot fi ameliorate în cazul în care afec\u0163iunea este tratat\u0103 cu succes.<\/p>\n

Caracteristici mai pu\u021bin frecvente sau complica\u021bii sunt:<\/p>\n

Respiratorie – hipertensiune pulmonar\u0103, boli pulmonare restrictive.<\/p>\n

Tromboz\u0103 – arterial\u0103 sau venoas\u0103.<\/p>\n

Insuficien\u021b\u0103 renal\u0103.<\/p>\n

Însuficien\u021b\u0103 cardiac\u0103 congestiv\u0103.<\/p>\n

Un sindrom de scurgere capilar\u0103.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-70449","disease","type-disease","status-publish","hentry"],"yoast_head":"\nSindromul POEMS - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Sindromul POEMS - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Sindromul POEMS   Sindromul POEMS, care este, de asemenea, cunoscut sub numele de sindromul Crow-Fukase, boala Takatsuki, sau sindromul PEP, este o afec\u0163iune rar\u0103 de sânge care lezeaz\u0103 nervii \u0219i afecteaz\u0103 multe alte p\u0103r\u021bi ale corpului. Acesta este definit ca o combina\u021bie de proliferare a plasmocitelor, polineuropatie, \u0219i efectele asupra multor alte sisteme de organe. 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Acesta este definit ca o combina\u021bie de proliferare a plasmocitelor, polineuropatie, \u0219i efectele asupra multor alte sisteme de organe. 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