{"id":77201,"date":"2017-03-29T13:32:32","date_gmt":"2017-03-29T13:32:32","guid":{"rendered":"http:\/\/humanitasnet-new.local\/cure\/fibrinogen\/"},"modified":"2017-03-29T13:32:32","modified_gmt":"2017-03-29T13:32:32","slug":"fibrinogen","status":"publish","type":"cure","link":"https:\/\/humanitas-net.humweb.webiz.team\/ro\/treatments\/fibrinogen\/","title":{"rendered":"Fibrinogen"},"content":{"rendered":"

Fibrinogen<\/h2>\n

 <\/p>\n

Ce este fibrinogenul?<\/h2>\n

Fibrinogenul (cunoscut \u0219i ca factor I) este o glicoprotein\u0103 la vertebrate, care ajut\u0103 la formarea cheagurilor de s\u00e2nge. Se compune dintr-o matrice liniar\u0103 de trei noduli \u021binute \u00eempreun\u0103 de un fir foarte sub\u021bire, care este estimat s\u0103 aib\u0103 un diametru cuprins \u00eentre 8 \u0219i 15 Angstrom. Este o glicoprotein\u0103 care este sintetizat\u0103 de ficat \u0219i joac\u0103 un rol important \u00een procesul de coagulare a s\u00e2ngelui. \u00cen timpul coagul\u0103rii sanguine normale \u00een corpul uman, o cascad\u0103 de coagulare activeaz\u0103 protrombina zimogen prin conversia \u00een trombina \u015ferin proteaz\u0103. Trombina converte\u0219te apoi fibrinogenul solubil \u00eentr-o caten\u0103 de fibrin\u0103 insolubil\u0103. Aceste fire sunt apoi reticulate prin factorul XIII pentru a forma un cheag de s\u00e2nge \u00een cazul \u00een care este necesar \u00een organism.<\/p>\n

Deficitul de fibrinogen congenital sau func\u021bia perturbat\u0103 a fibrinogenului poate duce fie la s\u00e2ngerare sau complica\u021bii tromboembolice, sau din punct de vedere clinic poate s\u0103 r\u0103m\u00e2n\u0103 f\u0103r\u0103 descoperiri patologice. Deficien\u021bele dob\u00e2ndite pot duce la hemodilu\u021bie, pierderi de s\u00e2nge \u0219i\/sau a consumului, cum ar fi la pacien\u021bii cu traumatisme, \u00een timpul unor faze ale coagul\u0103rii intravasculare diseminate (DIC), precum \u0219i \u00een septicemie. La pacien\u021bii cu deficit de fibrinogen, corectarea hemoragiei este posibil\u0103 prin infuzie de plasm\u0103 congelat\u0103 (FFP), crioprecipitat (o frac\u021biune de plasm\u0103, fibrinogen bogat) \u00een stare proasp\u0103t\u0103 sau de fibrinogen concentrate.<\/p>\n

<\/h2>\n

De ce trebuie m\u0103surat nivelul fibrinogenului?<\/h2>\n

Fibrinogen poate fi util pentru a descoperi defecte de coagulare, este adesea utilizat atunci c\u00e2nd alte teste de coagulare (de exemplu, timp de protrombin\u0103, timpul de tromboplastin\u0103, activat timp de tromboplastin\u0103 par\u021bial), care poate da rezultate anormale. Nivelurile de fibrinogen pot fi m\u0103surate \u00een s\u00e2nge venos. \u00cen situa\u021bii tipice, fibrinogenul este m\u0103surat\u0103 \u00een probele de plasm\u0103 citrat\u0103 \u00een laborator, cu toate acestea, analiza probelor \u00een s\u00e2ngele integral, prin utilizarea thromboelastometry (func\u021bia plachetar\u0103 este inhibat\u0103 cu cytochalasin D) este de asemenea posibil\u0103. Niveluri mai ridicate sunt, printre altele, asociate cu boli cardiovasculare \u015fi pot fi crescute sub orice form\u0103 de inflama\u021bie, deoarece este o protein\u0103 de faz\u0103 acut\u0103; de exemplu, este evident mai ales \u00een \u021besutul gingival uman \u00een timpul fazei ini\u021biale a bolii parodontale. Nivelurile de fibrinogen cre\u015fte \u00een timpul sarcinii la o medie de 4,5 g\/l, \u00een compara\u021bie cu o medie de 3 g\/l la persoanele care nu sunt gravide.<\/p>\n

Intervalul normal al nivelurilor de fibrinogen este de aproximativ 200 la 400 mg\/dl. Totu\u0219i, aceste valori depind de laborator \u0219i metodele utilizate. Rezultatele anormale pot fi legate de corp, folosind prea mult fibrinogenului precum cea de coagulare intravascular\u0103 diseminat\u0103 (DIC), sau din cauza deficien\u021bei de fibrinogen care pot fi achizi\u021bionate de la na\u0219tere sau ulterior. Alte cauze pot fi datorate descompunerii fibrin\u0103 (fibrinolizei), sau c\u0103 exist\u0103 o s\u00e2ngerare excesiv\u0103 (hemoragie).<\/p>\n

<\/h2>\n

Standarde de preg\u0103tire<\/h2>\n

Recoltarea se realizeaz\u0103 de obicei diminea\u021ba \u00een spital. Nu este nevoie de preg\u0103tiri special pentru acest test. Poate fi indicat s\u0103 \u021bine\u021bi un repaus alimentar \u00eenainte de examinare. \u00cen cazul \u00een care lua\u021bi medicamente informa\u021bi medicul \u00eenainte de examinare deoarece unele medicamente pot interfera cu rezultatele de s\u00e2nge.<\/p>\n

 <\/p>\n

Procedur\u0103 este dureroas\u0103 sau periculoas\u0103?<\/h2>\n

Examenul nu este nici dureros, nici periculos. Pacientul poate sim\u021bi o senza\u021bie de furnic\u0103turi la intrarea acului \u00een bra\u021bul atunci c\u00e2nd s\u00e2ngele este extras pentru examinare.<\/p>\n

 <\/p>\n

Cum se efectueaz\u0103 testul?<\/h2>\n

Testul const\u0103 dintr-o recoltare simpl\u0103 de s\u00e2nge.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-77201","cure","type-cure","status-publish","hentry"],"yoast_head":"\nFibrinogen - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Fibrinogen - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Fibrinogen   Ce este fibrinogenul? Fibrinogenul (cunoscut \u0219i ca factor I) este o glicoprotein\u0103 la vertebrate, care ajut\u0103 la formarea cheagurilor de s\u00e2nge. Se compune dintr-o matrice liniar\u0103 de trei noduli \u021binute \u00eempreun\u0103 de un fir foarte sub\u021bire, care este estimat s\u0103 aib\u0103 un diametru cuprins \u00eentre 8 \u0219i 15 Angstrom. 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Fibrinogenul (cunoscut \u0219i ca factor I) este o glicoprotein\u0103 la vertebrate, care ajut\u0103 la formarea cheagurilor de s\u00e2nge. Se compune dintr-o matrice liniar\u0103 de trei noduli \u021binute \u00eempreun\u0103 de un fir foarte sub\u021bire, care este estimat s\u0103 aib\u0103 un diametru cuprins \u00eentre 8 \u0219i 15 Angstrom. 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