{"id":76156,"date":"2017-03-24T16:06:58","date_gmt":"2017-03-24T16:06:58","guid":{"rendered":"http:\/\/humanitasnet-new.local\/cure\/haptoglobina\/"},"modified":"2017-03-24T16:06:58","modified_gmt":"2017-03-24T16:06:58","slug":"haptoglobina","status":"publish","type":"cure","link":"https:\/\/humanitas-net.humweb.webiz.team\/ro\/treatments\/haptoglobina\/","title":{"rendered":"Haptoglobina"},"content":{"rendered":"

Haptoglobina<\/h2>\n

 <\/p>\n

Ce este haptoglobina?<\/h2>\n

Haptoglobina (c\u00e2teodat\u0103 prescurtat\u0103 ca Hp) este o glicoprotein\u0103 care este produs\u0103 de ficat \u00een corpurile noastre. Haptoglobina este \u0219i proteina care este codificat\u0103 de gena HP la oameni. \u00cen plasma s\u00e2ngelui, func\u021bia haptoglobinei este de a lega hemoglobina liber\u0103 prezent\u0103 \u00een s\u00e2nge, care este eliberat\u0103 din eritrocite cu o afinitate ridicat\u0103 \u0219i astfel inhib\u0103 activitatea oxidativ\u0103. Apoi, complexul haptoglobin\u0103 \u2013 hemoglobin\u0103 va fi apoi eliminat prin sistemul reticuloendotelial, cel mai mult \u00een splin\u0103. \u00cen cadrul clinic, analizarea haptoglobinei este folosit\u0103 pentru a monitoriza \u0219i verifica anemia hemolitic\u0103 intravascular\u0103. La hemoliza intravascular\u0103, hemoglobina liber\u0103 va fi eliberat\u0103 \u00een circula\u021bie \u0219i haptoglobina se va lega de hemoglobin\u0103. \u00cen cazul hemolizei intravasculare, \u00een care exist\u0103 o cre\u0219tere \u00een eliberarea hemoglobinei din s\u00e2nge, haptoglobina este chemat\u0103 pentru preluarea \u0219i aducerea la ficat. Totu\u0219i, haptoglobina nu este o metod\u0103 de \u00eencredere pentru diferen\u021bierea dintre hemoliza intravascular\u0103 \u0219i extravascular\u0103.<\/p>\n

Aceast\u0103 func\u021bie a genei este de a codifica o protein\u0103 precursoare pentru a produce at\u00e2t lan\u021buri alfa \u0219i beta, care de fapt se combin\u0103 ca tetramer pentru a produce haptoglobina. Func\u021biile haptoglobinei de a lega plasma liber\u0103 a hemoglobine, care permite enzimelor degradante de a c\u00e2\u0219tiga acces la hemoglobin\u0103, \u0219i \u00een acela\u0219i timp \u00eempiedica pierderea de fier din rinichi \u0219i protejeaz\u0103 rinichi din a fi degrada\u021bi de c\u0103tre hemoglobin\u0103. Haptoglobina este produs\u0103 de hepatocite, dar poate fi produs\u0103 \u0219i de alte \u021besuturi ale corpului, cum ar fi pl\u0103m\u00e2nii, rinichii \u0219i pielea.<\/p>\n

<\/h2>\n

De ce este nevoie de m\u0103surarea nivelului de haptoglobin\u0103?<\/h2>\n

Examinarea pentru m\u0103surarea nivelului de haptoglobin\u0103 poate fi folositoare \u00een procesul de monitorizare a anemiei hemolitice. Valorile sc\u0103zute pot indica \u0219i un tip de distrugere \u00eenceat\u0103 a celulelor ro\u0219ii, f\u0103r\u0103 a avea leg\u0103tur\u0103 cu anemia. Spre exemplu, distrugerea poate fi cauzat\u0103 de valvele mecanice ale inimii \u0219i hemoglobina anormal\u0103, cum ar fi anemia falciform\u0103 sau talasemia. Haptoglobina este cunoscut\u0103 ca un reactiv sever al fazei. Nivelul acesteia cre\u0219te pe durata condi\u021biei severe, cum ar fi infec\u021bia, d\u0103unarea, distrugerea \u021besutului, unele tipuri de cancer, arsuri, opera\u021bie sau traume. Scopul este de a elimina celule avariate \u0219i a reziduurilor \u0219i de salva materiile importante, cum ar fi fierul. Nivelul de haptoglobin\u0103 poate fi folosit pentru a monitoriza cursul acestor condi\u021bii.<\/p>\n

C\u00e2nd celulele ro\u0219ii sunt distruse \u00een mod activ, haptoglobina dispare mai repede c\u00e2t a fost creat\u0103, a\u0219adar nivelul de haptoglobin\u0103 din s\u00e2nge descre\u0219te.<\/p>\n

<\/h2>\n

Standarde de preg\u0103tire<\/h2>\n

Recoltarea de probe este efectuat\u0103 diminea\u021ba, la spital. Este necesar ca pacientul s\u0103 nu m\u0103n\u00e2nce \u00eenainte de examinare, iar acesta va fi \u00eendrumat de doctor. Este important s\u0103 informa\u021bi doctorul \u00een leg\u0103tur\u0103 cu orice tip de medicamente pe care le lua\u021bi deoarece acestea ar putea afecta rezultatele examin\u0103rii. Medicamentele care ar putea cre\u0219te nivelul de haptoglobin\u0103 sunt Androgenii \u0219i Corticosteroizii. Totu\u0219i, medicamentele care pot sc\u0103dea nivelul de haptoglobin\u0103 sunt izoniazidii, nitrofurantoin, anticoncep\u021bionalele, clorpromazina, chinidina, streptomicina, difenhidramina \u0219i indometacinul. Nu \u00eenceta\u021bi s\u0103 mai lua\u021bi aceste medicamente \u00eenainte de programarea la doctor, care v\u0103 va recomanda ce pa\u0219i s\u0103 urma\u021bi pe mai departe. Istoricul medial va fi necesar dac\u0103 doctorul \u00eel cere.<\/p>\n

<\/h2>\n

Este aceast\u0103 examinare dureroas\u0103 sau periculoas\u0103?<\/h2>\n

Examinarea nu este nici dureroas\u0103, nici periculoas\u0103. Pacientul poate sim\u021bi o senza\u021bie de usturime la intrarea acului \u00een m\u00e2n\u0103.<\/p>\n

<\/h2>\n

Cum este efectuat\u0103 examinarea?<\/h2>\n

Examinarea este realizat\u0103 printr-o simpl\u0103 analiz\u0103 de s\u00e2nge.<\/p>\n","protected":false},"featured_media":0,"template":"","class_list":["post-76156","cure","type-cure","status-publish","hentry"],"yoast_head":"\nHaptoglobina - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"ro_RO\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Haptoglobina - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"Haptoglobina   Ce este haptoglobina? Haptoglobina (c\u00e2teodat\u0103 prescurtat\u0103 ca Hp) este o glicoprotein\u0103 care este produs\u0103 de ficat \u00een corpurile noastre. 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