{"id":82975,"date":"2019-01-31T17:10:35","date_gmt":"2019-01-31T17:10:35","guid":{"rendered":"http:\/\/humanitasnet-new.local\/enciclopedia\/gemcitabine-2\/"},"modified":"2019-01-31T17:10:35","modified_gmt":"2019-01-31T17:10:35","slug":"gemcitabine-2","status":"publish","type":"enciclopedia","link":"https:\/\/humanitas-net.humweb.webiz.team\/fr\/wiki\/gemcitabine-2\/","title":{"rendered":"Gemcitabine"},"content":{"rendered":"<p>La gemcitabine est un agent antin\u00e9oplasique m\u00e9tabolis\u00e9 par voie intracellulaire. Son activit\u00e9 cytotoxique est due \u00e0 l&#8217;inhibition de la synth\u00e8se des cellules d&#8217;ADN par ses deux m\u00e9tabolites actifs, le difluorod\u00e9ossicitidindifosfate et le difluorod\u00e9ossicitidintrifosfate.<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"quest-ce-que-la-gemcitabine\">Qu&#8217;est-ce que la gemcitabine ?<\/h2>\n<p>La gemcitabine est un m\u00e9dicament antin\u00e9oplasique antim\u00e9tabolite du groupe de la pyrimidine. Il est administr\u00e9 pour le traitement de divers cancers, en particulier pour :<\/p>\n<ul>\n<li>Cancer de la vessie<\/li>\n<li>Cancer du sein<\/li>\n<li>Cancer de l&#8217;ovaire<\/li>\n<li>Cancer du poumon (non \u00e0 petites cellules)<\/li>\n<li>Cancer du pancr\u00e9as<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>Elle peut \u00eatre administr\u00e9e seul ou en association avec d&#8217;autres m\u00e9dicaments anticanc\u00e9reux.<\/p>\n<p>&nbsp;<\/p>\n<h2 id=\"comment-faut-il-prendre-la-gemcitabine\">Comment faut-il prendre la gemcitabine ?<\/h2>\n<p>La gemcitabine est administr\u00e9e :<\/p>\n<ul>\n<li>Par voie intraveineuse (perfusion)<\/li>\n<li>Intrav\u00e9sicalement (cath\u00e9ter)<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<h2 id=\"les-effets-secondaires-associes-a-la-gemcitabine\">Les effets secondaires associ\u00e9s \u00e0 la gemcitabine<\/h2>\n<p>Comme tous les m\u00e9dicaments de chimioth\u00e9rapie, la gemcitabine peut aussi causer de la fatigue (asth\u00e9nie) et peut diminuer l&#8217;app\u00e9tit, qui peut survenir sous forme l\u00e9g\u00e8re ou s\u00e9v\u00e8re. La faiblesse peut \u00eatre li\u00e9e \u00e0 l&#8217;an\u00e9mie. Les effets ind\u00e9sirables varient d&#8217;un sujet \u00e0 l&#8217;autre, selon la tol\u00e9rance individuelle.<\/p>\n<h2 id=\"\"><\/h2>\n<h2 id=\"les-effets-indesirables-les-plus-courants-sont-enumeres-ci-dessous\">Les effets ind\u00e9sirables les plus courants sont \u00e9num\u00e9r\u00e9s ci-dessous :<\/h2>\n<ul>\n<li>R\u00e9duction temporaire de la production de cellules sanguines par les os (la diminution de la moelle rouge entra\u00eene une diminution de l&#8217;h\u00e9moglobine et donc de l&#8217;an\u00e9mie, la diminution des globules blancs facilite le d\u00e9veloppement des infections, la diminution des plaquettes provoque des h\u00e9matomes ou des saignements). Vos cellules sanguines augmenteront alors r\u00e9guli\u00e8rement et seront habituellement revenues \u00e0 la normale dans les 21 \u00e0 28 jours suivant le d\u00e9but du traitement ;<\/li>\n<li>Naus\u00e9es et vomissements ;<\/li>\n<li>Sympt\u00f4mes semblables \u00e0 ceux de la grippe.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>Les effets secondaires moins fr\u00e9quents comprennent notamment :<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Diminution temporaire de la fonction h\u00e9patique (qui sera de toute fa\u00e7on normalis\u00e9e \u00e0 la fin du traitement) ;<\/li>\n<li>Changements de peau semblables aux \u00e9ruptions d&#8217;acn\u00e9, qui peuvent \u00eatre irritantes ;<\/li>\n<li>Douleur ou ulc\u00e8re dans la bouche, avec ou sans alt\u00e9ration l\u00e9g\u00e8re du go\u00fbt ;<\/li>\n<li>Diarrh\u00e9e ;<\/li>\n<li>Somnolence ;<\/li>\n<li>Perte de cheveux ;<\/li>\n<li>Modifications de la fonction r\u00e9nale (occasionnelles et r\u00e9versibles)<\/li>\n<\/ul>\n<h2 id=\"\"><\/h2>\n<h2 id=\"contre-indications-et-mises-en-garde-associees-a-lutilisation-de-gemcitabine\">Contre-indications et mises en garde associ\u00e9es \u00e0 l&#8217;utilisation de gemcitabine<\/h2>\n<p>Certains m\u00e9dicaments peuvent interf\u00e9rer avec le traitement par la gemcitabine, il est donc fortement conseill\u00e9 de communiquer soigneusement avec l&#8217;oncologue quels m\u00e9dicaments vous prenez r\u00e9guli\u00e8rement et de consulter avant de prendre tout nouveau m\u00e9dicament. M\u00e9fiez-vous du rayonnement solaire : les m\u00e9dicaments de chimioth\u00e9rapie se r\u00e9pandent dans tous les tissus par la circulation sanguine, y compris la peau ; par cons\u00e9quent, un contact prolong\u00e9 avec les rayons du soleil peut causer des rougeurs, des \u00e9ruptions et des coups de soleil. De plus, il n&#8217;est pas recommand\u00e9 d&#8217;allaiter pendant le traitement par la gemcitabine.<\/p>\n","protected":false},"featured_media":0,"parent":0,"template":"","Example":[1800],"class_list":["post-82975","enciclopedia","type-enciclopedia","status-publish","hentry","enciclopedia_category-ingredients-actifs"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v24.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Gemcitabine - Humanitas.net<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"fr_FR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Gemcitabine - Humanitas.net\" \/>\n<meta property=\"og:description\" content=\"La gemcitabine est un agent antin\u00e9oplasique m\u00e9tabolis\u00e9 par voie intracellulaire. 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