Me at Humanitas

Macro Operational Unit

Endocrinology

Personal Publications on PubMed

Overall, the scientific activity has resulted in the publication of over 145 full-text papers, of which 144 were published in international journals with an impact factor indexed by PubMed:

https://www.ncbi.nlm.nih.gov/pubmed/?term=mazziotti+gherardo

Bibliometric Indices of Total Scientific Production

Source: Scopus [https://www.scopus.com/authid/detail.uri?authorId=6701486206]
(update 23/01/2021)

• Career H-index: 44
• Citations: 6767
• Number of papers: 170

Diseases

• Osteoporosis, Pituitary Diseases, Thyroid Diseases

Areas of Medical Interest

• Osteometabolic diseases: primary and secondary osteoporosis
• Pituitary diseases
• Thyroid diseases
• Parathyroid diseases

Research Areas of Interest

In the early academic years (from 2000 to 2005), Prof. Mazziotti’s scientific activity was mainly focused on the study of autoimmune thyroid diseases, with numerous scientific contributions clarifying many of the pathophysiological aspects of autoimmune thyroid disorders through the use of a clinical-experimental model such as interferon-alpha-induced thyroiditis. Specifically, studies conducted at the thyroid autoimmunity laboratory at the University of Wales College of Medicine demonstrated that analyzing peripheral lymphocytes can characterize the autoimmune response in patients with Hashimoto’s thyroiditis.

In the subsequent years (from 2005 to the present), Prof. Mazziotti’s scientific activity has been dedicated to clinical studies on osteometabolic and pituitary diseases, with a particular focus on the neuroendocrinology of bone and secondary osteoporosis due to endocrine disorders, resulting in numerous papers published as original studies, reviews, and meta-analyses. The main findings of these studies can be summarized as follows:

• First demonstration in humans of a direct effect of thyroid-stimulating hormone (TSH) on bone remodeling, with a high fracture risk related to low TSH levels.
• First demonstration in clinical models that hyperprolactinemia can cause skeletal fragility with an increased risk of vertebral fractures, independently of hypogonadism.
• Definition of acromegalic osteopathy, characterized by high bone turnover, deterioration of bone microstructure, and a high risk of vertebral fractures (radiological-morphometric).
• Demonstration of a high risk of vertebral fractures in adult patients with hypopituitarism due to growth hormone deficiency and overuse of glucocorticoid and thyroid hormone replacement therapy.
• Demonstration that glucocorticoids can cause skeletal fragility even when administered in replacement doses.
• First demonstration that patients with the rare Ehlers-Danlos disease are at risk for vertebral fractures due to fragility.
• Demonstration that the pulsatility of parathyroid hormone is modulated by growth hormone.

Prof. Mazziotti has also participated in multicenter studies concerning:

• The management of bone metastases in patients with thyroid carcinoma
• The efficacy and safety of first-generation somatostatin analogs used in non-conventional regimens (high doses or high frequency of administration) in the treatment of acromegaly

Additionally, he has been involved in international collaborations in drafting documents related to secondary osteoporosis and endocrine diseases. Prof. Mazziotti has also participated in consensus conferences that have produced guidelines on the diagnosis and treatment of acromegaly.

Specialization

Endocrinology and Metabolic Diseases

Role in Hospital

Head of Section

Education

University

University of Campania L. Vanvitelli (formerly Second University of Naples)

Specialization

Endocrinology and Metabolic Diseases, Endocrinology Pathway

Date of Specialization

October 2000

University

University of Campania L. Vanvitelli (formerly Second University of Naples)

Previous Experience

Country

Italy

Province

MN

City

Mantova

Hospital/Institution Name

ASST Carlo Poma of Mantova

From

December 2007

Until

January 2019

Last Role and Activity Description

Medical Director and later Head of the Simple Structure of Endocrinology

Academic Role

Role

Associate Professor of Endocrinology, competitive sector 06/D2, profile MED/13

From

01/02/2019

University/Institution Name

Humanitas University